Van de Ven Brace Ends Everton's Run at Brand New Home Ground
The Dutch defender emerged as the first backline player to score two goals in a English top-flight match for Spurs since the Belgian defender in March 2013.
Match summary
Micky Van de Ven nods into the net twice in opening period
The home side's Jake O'Brien has equalizer disallowed after VAR review
Senegalese midfielder scores third in 89th minute
The defeat is the Merseyside club's initial at Hill Dickinson Stadium
Micky van de Ven scored on two occasions as Spurs prolonged their winning streak on the road in the top division and delivered Everton their first defeat at Hill Dickinson Stadium.
Everton were undefeated in their five previous fixtures at their recently opened stadium at the dockside location, having left Goodison Park behind after 133 years at the end of last season.
But Spurs captain Van de Ven pounced twice from set-pieces in the first half to place their impressive record at jeopardy, and they were unable to mount a comeback before the midfielder - set up by ex-Everton forward Richarlison - headed home a third to put the game to bed.
Jake O'Brien thought he had levelled the tally a short while after Van de Ven's opener, directing a powerful header past Guglielmo Vicario from an set-piece.
Beto, meanwhile, failed to convert a handful of opportunities, while the Italian goalkeeper made a series of fine stops to guarantee Tottenham went five away games without defeat in the Premier League.
But the VAR intervened, instructing Craig Pawson to review the goal on the pitchside monitor and the official decided that Jack Grealish and the attacker were in offside positions and had interfered with the Tottenham goalkeeper.
This victory elevates the manager's team up to third in the Premier League, a handful of points off local foes and table-toppers the Gunners.
The Merseyside club remain 14th and are half a dozen points clear of the drop zone.
Tottenham analysis: Van de Ven fulfils duties at each end of the field
After a uninspiring weekday display in the European competition against Monaco, where they managed a mere attempts on target, the manager opted for Randal Kolo Muani up front instead of former Toffees player Richarlison.
The summer signing was unable to make much of an impact before being replaced for Richarlison after 60 minutes on the field, but it turns out he wasn't needed in the final outcome.
Defender the Dutchman converted into an offensive threat to be reckoned with.
Spurs' opening strike came from a well-worked corner routine, with Rodrigo Bentancur directing the ball toward the face of goal for an unmarked the defender to score.
And the captain - filling in as captain in Cristian Romero's unavailability - added his next goal in added time as he outjumped the England keeper to head home.
The Dutchman was equally outstanding in defence, combining well with his defensive colleague as the duo dealt excellently with the 34 crosses sent their way by Everton.
Toffees breakdown: Everton lacking finishing touch
The club's new home had been a fortress, but it appears the freshness may have worn off slightly and fans headed to the gates after the midfielder's final goal for Tottenham.
The end in Everton's winning streak at home will not be a massive concern for David Moyes, but their striker situation will be.
Beto and Thierno Barry - the Toffees' two recognised strikers - had netted only a single goal between them before the weekend's outing.
And they were failed to add to that poor tally on a damp and dreary night on in Liverpool.
The striker's form was summed up when he chose to bicycle-kick a clear chance from near the goal, despite having space and opportunity to reposition for a more conventional shot that would have tested Vicario.
Barry, as well, failed to make an impact after replacing the starter in the 65th minute.
It was not for a lack of chance. Most of the home side's offensive moves came through Grealish and Ndiaye, who tirelessly whipped threatening crosses into the Spurs box.
What next for both teams?
Everton: Moyes' men head to the Stadium of Light in the top flight on early November at 20:00 GMT.
Tottenham: The London club travel to St James' Park on late October for their fourth-round League Cup tie against the Magpies.